Unsupervised ensemble learning for genome sequencing

نویسندگان

چکیده

• The variant calling step in next generation sequencing technologies is formulated as a classification problem. An unsupervised ensemble method proposed caller for DNA sequencing. EM-based algorithm that estimates the maximum posteriori class to take decision presented. number of classes be decided greater than different labels are observed. Experimental results with real human data support approach. Unsupervised learning refers methods devised particular task combine provided by learners taking into account their reliability, which usually inferred from data. Here, an A based on expectation-maximization further maximum-a-posteriori among larger learners. show competitive compared state-of-the-art callers GATK, HTSLIB, and Platypus.

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ژورنال

عنوان ژورنال: Pattern Recognition

سال: 2022

ISSN: ['1873-5142', '0031-3203']

DOI: https://doi.org/10.1016/j.patcog.2022.108721